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Tohoku University Technology: CuO-added Biocompatible Ti Alloy: T24-104

Both mechanical properties and antibacterial properties are improved. Can be produced with a 3D printer.

Titanium (Ti) alloys are widely used in the medical field due to their lightweight, non-magnetic, corrosion-resistant, and biocompatible properties. However, Ti has low antibacterial properties, making it prone to bacterial infections when used in dental implants, and it also has low resistance to inflammation, leading to rapid progression once an infection occurs. Additionally, there are concerns about limited durability due to insufficient strength, and the manufacturing of dental implants, for example, requires multi-stage processing, which is costly. This invention confirms that samples made from Ti-CuO composite powder through additive manufacturing exhibit excellent mechanical properties and antibacterial characteristics. The improvement in mechanical properties is attributed to the solid solution strengthening element O, while the enhancement of antibacterial properties is believed to result from the rapid cooling and solidification by laser during additive manufacturing, which prevents the formation of coarse Ti-Cu intermetallic compounds due to the supersaturation of Cu.

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Tohoku University Technology: Titanium alloy for biomedical application: T19-802

High antibacterial property, biocompatibility and a low Young's modulus close to the cortical bone

 A requirement for biocompatible Ti alloy for orthopedic implants is to suppress stress shielding, which occurs because of the large difference between Young’s moduli of the prosthetic stem and the cortical bone (10–30 GPa). Meanwhile, conventional autoclave sterilization before implant exhibits the discoloration and heaviest particulate contamination, and some multiple sterilization regimens for metallic materials may pose serious biological concerns.  The present invention can provide the necessary functions to a Ti implant material without impairing the low Young's modulus of Ti alloy. It possesses high antibacterial properties with a high antibacterial activity value above 2.0 from the antibacterial test (JIS R 1702) and osseointegration fromhydroxyapatite formation on the surface of Ti alloy in simulated body fluid.

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